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Ozempic initially had a stable but relatively small user base, comprised primarily patients with T2D who could not take or werent responding to the existing first line treatment metformin

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While SGLT2-i and GLP-1RA may offer additive or synergistic benefits in reducing BP and cardiovascular risk, current guidelines do not support their role as first-line antihypertensive agents or early adjunctive therapies over established agents such as thiazide diuretics, renin-angiotensin system (RAS) inhibitors, or calcium channel blockers (CCBs)

A firstinhuman, randomized, doubleblind, single and multipledose, phase I study of recombinant human thymosin 4 in healthy Chinese volunteers